Viral persistence in vivo through selection of neutralizing antibody-escape variants.
Despite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1826302174766825472 |
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| author | Ciurea, A Klenerman, P Hunziker, L Horvath, E Senn, B Ochsenbein, A Hengartner, H Zinkernagel, R |
| author_facet | Ciurea, A Klenerman, P Hunziker, L Horvath, E Senn, B Ochsenbein, A Hengartner, H Zinkernagel, R |
| author_sort | Ciurea, A |
| collection | OXFORD |
| description | Despite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore, the phenomenon of viral evasion from the nAb response and its implications for virus persistence remain controversial. Here we demonstrate nAb-mediated viral clearance in CTL-deficient mice infected with the prototypic noncytopathic lymphocytic choriomeningitis virus (strain WE). During prolonged CTL absence, neutralization-resistant virus mutants were selected in individual mice within 70-90 days. In naive animals infected with these virus variants only low nAb responses were induced, resulting in an increased tendency of virus to persist. |
| first_indexed | 2024-03-07T05:43:33Z |
| format | Journal article |
| id | oxford-uuid:e66d4dda-42a2-4fb1-95b8-31b351053c85 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:43:33Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:e66d4dda-42a2-4fb1-95b8-31b351053c852022-03-27T10:31:00ZViral persistence in vivo through selection of neutralizing antibody-escape variants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e66d4dda-42a2-4fb1-95b8-31b351053c85EnglishSymplectic Elements at Oxford2000Ciurea, AKlenerman, PHunziker, LHorvath, ESenn, BOchsenbein, AHengartner, HZinkernagel, RDespite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore, the phenomenon of viral evasion from the nAb response and its implications for virus persistence remain controversial. Here we demonstrate nAb-mediated viral clearance in CTL-deficient mice infected with the prototypic noncytopathic lymphocytic choriomeningitis virus (strain WE). During prolonged CTL absence, neutralization-resistant virus mutants were selected in individual mice within 70-90 days. In naive animals infected with these virus variants only low nAb responses were induced, resulting in an increased tendency of virus to persist. |
| spellingShingle | Ciurea, A Klenerman, P Hunziker, L Horvath, E Senn, B Ochsenbein, A Hengartner, H Zinkernagel, R Viral persistence in vivo through selection of neutralizing antibody-escape variants. |
| title | Viral persistence in vivo through selection of neutralizing antibody-escape variants. |
| title_full | Viral persistence in vivo through selection of neutralizing antibody-escape variants. |
| title_fullStr | Viral persistence in vivo through selection of neutralizing antibody-escape variants. |
| title_full_unstemmed | Viral persistence in vivo through selection of neutralizing antibody-escape variants. |
| title_short | Viral persistence in vivo through selection of neutralizing antibody-escape variants. |
| title_sort | viral persistence in vivo through selection of neutralizing antibody escape variants |
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