Viral persistence in vivo through selection of neutralizing antibody-escape variants.

Viral persistence in vivo through selection of neutralizing antibody-escape variants.

Despite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore...

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Bibliographic Details
Main Authors:	Ciurea, A, Klenerman, P, Hunziker, L, Horvath, E, Senn, B, Ochsenbein, A, Hengartner, H, Zinkernagel, R
Format:	Journal article
Language:	English
Published:	2000

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