Likelihoods and simulation methods for a class of nonneutral population genetics models.
Methods for simulating samples and sample statistics, under mutation-selection-drift equilibrium for a class of nonneutral population genetics models, and for evaluating the likelihood surface, in selection and mutation parameters, are developed and applied for observed data. The methods apply to la...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1826302191316500480 |
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| author | Donnelly, P Nordborg, M Joyce, P |
| author_facet | Donnelly, P Nordborg, M Joyce, P |
| author_sort | Donnelly, P |
| collection | OXFORD |
| description | Methods for simulating samples and sample statistics, under mutation-selection-drift equilibrium for a class of nonneutral population genetics models, and for evaluating the likelihood surface, in selection and mutation parameters, are developed and applied for observed data. The methods apply to large populations in settings in which selection is weak, in the sense that selection intensities, like mutation rates, are of the order of the inverse of the population size. General diploid selection is allowed, but the approach is currently restricted to models, such as the infinite alleles model and certain K-models, in which the type of a mutant allele does not depend on the type of its progenitor allele. The simulation methods have considerable advantages over available alternatives. No other methods currently seem practicable for approximating likelihood surfaces. |
| first_indexed | 2024-03-07T05:43:48Z |
| format | Journal article |
| id | oxford-uuid:e67f4775-5086-4228-bc5c-2d9f60fc5b97 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:43:48Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:e67f4775-5086-4228-bc5c-2d9f60fc5b972022-03-27T10:31:36ZLikelihoods and simulation methods for a class of nonneutral population genetics models.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e67f4775-5086-4228-bc5c-2d9f60fc5b97EnglishSymplectic Elements at Oxford2001Donnelly, PNordborg, MJoyce, PMethods for simulating samples and sample statistics, under mutation-selection-drift equilibrium for a class of nonneutral population genetics models, and for evaluating the likelihood surface, in selection and mutation parameters, are developed and applied for observed data. The methods apply to large populations in settings in which selection is weak, in the sense that selection intensities, like mutation rates, are of the order of the inverse of the population size. General diploid selection is allowed, but the approach is currently restricted to models, such as the infinite alleles model and certain K-models, in which the type of a mutant allele does not depend on the type of its progenitor allele. The simulation methods have considerable advantages over available alternatives. No other methods currently seem practicable for approximating likelihood surfaces. |
| spellingShingle | Donnelly, P Nordborg, M Joyce, P Likelihoods and simulation methods for a class of nonneutral population genetics models. |
| title | Likelihoods and simulation methods for a class of nonneutral population genetics models. |
| title_full | Likelihoods and simulation methods for a class of nonneutral population genetics models. |
| title_fullStr | Likelihoods and simulation methods for a class of nonneutral population genetics models. |
| title_full_unstemmed | Likelihoods and simulation methods for a class of nonneutral population genetics models. |
| title_short | Likelihoods and simulation methods for a class of nonneutral population genetics models. |
| title_sort | likelihoods and simulation methods for a class of nonneutral population genetics models |
| work_keys_str_mv | AT donnellyp likelihoodsandsimulationmethodsforaclassofnonneutralpopulationgeneticsmodels AT nordborgm likelihoodsandsimulationmethodsforaclassofnonneutralpopulationgeneticsmodels AT joycep likelihoodsandsimulationmethodsforaclassofnonneutralpopulationgeneticsmodels |