Water gated contrast switching with polymer–silica hybrid nanoparticles
Bioresponsive contrast agents can provide smart signaling in MRI. In wrapping pore functionalised Gd-DOTA mesoporous silica nanoparticles with pH-responsive poly(acrylic acid), exchange between pore and bulk water can be reversibly switched by local pH. The generated high contrast then exhibits a la...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2019
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| _version_ | 1797100875725930496 |
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| author | Pellico, J Ellis, CM Miller, J Davis, JJ |
| author_facet | Pellico, J Ellis, CM Miller, J Davis, JJ |
| author_sort | Pellico, J |
| collection | OXFORD |
| description | Bioresponsive contrast agents can provide smart signaling in MRI. In wrapping pore functionalised Gd-DOTA mesoporous silica nanoparticles with pH-responsive poly(acrylic acid), exchange between pore and bulk water can be reversibly switched by local pH. The generated high contrast then exhibits a large amplitude switch in a manner relevant to environmentally responsive imaging.
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| first_indexed | 2024-03-07T05:43:53Z |
| format | Journal article |
| id | oxford-uuid:e685f337-4385-42a9-bf56-a289492d487a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:43:53Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:e685f337-4385-42a9-bf56-a289492d487a2022-03-27T10:31:55ZWater gated contrast switching with polymer–silica hybrid nanoparticlesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e685f337-4385-42a9-bf56-a289492d487aEnglishSymplectic ElementsRoyal Society of Chemistry2019Pellico, JEllis, CMMiller, JDavis, JJBioresponsive contrast agents can provide smart signaling in MRI. In wrapping pore functionalised Gd-DOTA mesoporous silica nanoparticles with pH-responsive poly(acrylic acid), exchange between pore and bulk water can be reversibly switched by local pH. The generated high contrast then exhibits a large amplitude switch in a manner relevant to environmentally responsive imaging. |
| spellingShingle | Pellico, J Ellis, CM Miller, J Davis, JJ Water gated contrast switching with polymer–silica hybrid nanoparticles |
| title | Water gated contrast switching with polymer–silica hybrid nanoparticles |
| title_full | Water gated contrast switching with polymer–silica hybrid nanoparticles |
| title_fullStr | Water gated contrast switching with polymer–silica hybrid nanoparticles |
| title_full_unstemmed | Water gated contrast switching with polymer–silica hybrid nanoparticles |
| title_short | Water gated contrast switching with polymer–silica hybrid nanoparticles |
| title_sort | water gated contrast switching with polymer silica hybrid nanoparticles |
| work_keys_str_mv | AT pellicoj watergatedcontrastswitchingwithpolymersilicahybridnanoparticles AT elliscm watergatedcontrastswitchingwithpolymersilicahybridnanoparticles AT millerj watergatedcontrastswitchingwithpolymersilicahybridnanoparticles AT davisjj watergatedcontrastswitchingwithpolymersilicahybridnanoparticles |