Investigation into the regulatory mechanism of BRCA2 stability

Investigation into the regulatory mechanism of BRCA2 stability

<p>Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovarian cancers. The BRCA2 protein plays a fundamental role in the repair of DNA double strand breaks by homologous recombination (HR). BRCA2 mediates the recruitment of the RAD51 recombinase to DN...

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Bibliografiske detaljer
Hovedforfatter:	Gruber, C
Andre forfattere:	Esashi, F
Format:	Thesis
Sprog:	English
Udgivet:	2013
Fag:	Medical Sciences Biology (medical sciences) Biochemistry DNA damage signalling

Lignende værker

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Selective targeting of homologous recombination deficiency
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Mouse models for the investigation of MAPT and its role in neurodegenerative disease
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Development of bioreductive inhibitors of checkpoint kinase 1 to target hypoxic tumours
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Base excision repair of radiation-induced DNA damage in mammalian cells
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The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target
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An analysis of the S. cerevisiae RMI1 gene
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Structural and functional studies of Wnt signalling pathway antagonists
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Impact of TMPRSS2-ERG fusion gene on prostate cancer cell response to chemotherapy, radiotherapy and androgen deprivation therapy
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KDM2B links recognition of CpG islands to polycomb domain formation in vivo
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bHLH and bHLH-LZ factor exchange at promoters
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Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection.
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Rapid fluorescent vital imaging of olfactory epithelium
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Investigation of the role of ASPP2 in tumourigenesis
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The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits
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Understanding the role of CFP1 at CpG islands
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Structure-function studies of fibronectin domains in the human endometrium
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Identification of Plasmodium falciparum HSP70-2 as a resident of the Plasmodium export compartment
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Inferring structural properties of protein-DNA binding using high-throughput sequencing. The paradigm of GATA1, KLF1 and their complexes GATA1/FOG1 and GATA1/KLF1. Insights into the transcriptional regulation of the erythroid cell lineage.
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Generation of a novel endogenously StrepII/FLAG tagged system for the identification of the vertebrate FANCJ associated proteins
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New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients
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A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
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