Investigation into the regulatory mechanism of BRCA2 stability

Investigation into the regulatory mechanism of BRCA2 stability

<p>Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovarian cancers. The BRCA2 protein plays a fundamental role in the repair of DNA double strand breaks by homologous recombination (HR). BRCA2 mediates the recruitment of the RAD51 recombinase to DN...

Bibliografski detalji
Glavni autor:	Gruber, C
Daljnji autori:	Esashi, F
Format:	Disertacija
Jezik:	English
Izdano:	2013
Teme:	Medical Sciences Biology (medical sciences) Biochemistry DNA damage signalling

Slični predmeti

Tet2 and relevant potential intervention in cancer
od: Zauri, M
Izdano: (2014)

DNA damage responses to loss of telomere integrity
od: Carlos, AR
Izdano: (2013)

Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa
od: Lin Jin, i dr.
Izdano: (2023-06-01)

Novel regulation of SRC family kinase signalling by RASSF1 isoforms
od: Scrace, SF
Izdano: (2013)

SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
od: Meijing Wang, i dr.
Izdano: (2022-04-01)

Hypoxia-induced chromatin changes and ATM signalling
od: Olcina del Molino, M
Izdano: (2014)

Study of DNA double strand break repair in Dictyostelium discoideum
od: Lempidaki, S
Izdano: (2012)

Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells
od: Meng Zhang, i dr.
Izdano: (2023-10-01)

Selective targeting of homologous recombination deficiency
od: Zimmer, J
Izdano: (2014)

The three methyls: the function and therapeutic potential of histone H3K36 trimethylation
od: Pfister, SX
Izdano: (2014)

The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1
od: Meisenberg, C
Izdano: (2012)

MiR-215 regulates differentiation in colorectal cancer stem cells
od: Jones, M
Izdano: (2014)

An investigation into the molecular mechanism of the fibrillin1 - LTBP1 interaction
od: Robertson, I, i dr.
Izdano: (2012)

The role of p53 in hypoxia-induced apoptosis
od: Poole, R
Izdano: (2010)

Mouse models for the investigation of MAPT and its role in neurodegenerative disease
od: Wobst, H
Izdano: (2013)

Development of bioreductive inhibitors of checkpoint kinase 1 to target hypoxic tumours
od: Körner, C
Izdano: (2015)

Base excision repair of radiation-induced DNA damage in mammalian cells
od: Cooper, S, i dr.
Izdano: (2013)

Biochemical characterization of a novel deubiquitinating enzyme otubain 1 and investigation into its role in Yersinia infection
od: Edelmann, M, i dr.
Izdano: (2010)

Elucidating the role of GBA in the pathology of Parkinson's disease using patient derived dopaminergic neurons differentiated from induced pluripotent stem cells.
od: Ribeiro Fernandes, HJ
Izdano: (2014)

The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target
od: O'Brien, EM
Izdano: (2012)

An analysis of the S. cerevisiae RMI1 gene
od: Ashton, TM
Izdano: (2010)

Structural and functional studies of Wnt signalling pathway antagonists
od: Malinauskas, T
Izdano: (2011)

Impact of TMPRSS2-ERG fusion gene on prostate cancer cell response to chemotherapy, radiotherapy and androgen deprivation therapy
od: Ovtcharov, S
Izdano: (2015)

KDM2B links recognition of CpG islands to polycomb domain formation in vivo
od: Farcas, AM
Izdano: (2013)

Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
od: Leilei Qi, i dr.
Izdano: (2022-09-01)

Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues
od: Anna Duran-Corbera, i dr.
Izdano: (2022-10-01)

bHLH and bHLH-LZ factor exchange at promoters
od: Louphrasitthiphol, P
Izdano: (2015)

Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection.
od: Fu, JKY
Izdano: (2013)

E2F7: a member of the E2F family with a novel mechanism of transcriptional repression
od: Kesoglidou, PX
Izdano: (2012)

Rapid fluorescent vital imaging of olfactory epithelium
od: Hironobu Nishijima, i dr.
Izdano: (2022-05-01)

Investigation of the role of ASPP2 in tumourigenesis
od: Tordella, L
Izdano: (2012)

The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits
od: Beer, N, i dr.
Izdano: (2011)

Understanding the role of CFP1 at CpG islands
od: Brown, D
Izdano: (2014)

Structure-function studies of fibronectin domains in the human endometrium
od: Mok, M, i dr.
Izdano: (2008)

Identification of Plasmodium falciparum HSP70-2 as a resident of the Plasmodium export compartment
od: Gladys T. Cortés, i dr.
Izdano: (2020-06-01)

Inferring structural properties of protein-DNA binding using high-throughput sequencing. The paradigm of GATA1, KLF1 and their complexes GATA1/FOG1 and GATA1/KLF1. Insights into the transcriptional regulation of the erythroid cell lineage.
od: Oikonomopoulos, S
Izdano: (2014)

Generation of a novel endogenously StrepII/FLAG tagged system for the identification of the vertebrate FANCJ associated proteins
od: Jalal, K
Izdano: (2012)

New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients
od: Gangadharan, B, i dr.
Izdano: (2011)

A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
od: Wendi Zhang, i dr.
Izdano: (2023-11-01)

Regulation of E2F-1 by methylation and NEDDylation
od: Loftus, S, i dr.
Izdano: (2012)