The evolution of left-right asymmetry in chordates.
The internal organs of all vertebrates are asymmetrically organised across the left-right axis. The development of this asymmetry is controlled by a molecular pathway that includes the signalling molecule Nodal and the transcription factor Pitx2, proteins encoded by genes that are predominantly expr...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1797100894556258304 |
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| author | Boorman, C Shimeld, S |
| author_facet | Boorman, C Shimeld, S |
| author_sort | Boorman, C |
| collection | OXFORD |
| description | The internal organs of all vertebrates are asymmetrically organised across the left-right axis. The development of this asymmetry is controlled by a molecular pathway that includes the signalling molecule Nodal and the transcription factor Pitx2, proteins encoded by genes that are predominantly expressed on the left side of all vertebrate embryos studied to date. Vertebrates share Phylum Chordata with two other groups of animals, amphioxus and the urochordates (including ascidians). Both these taxa develop left-right asymmetries, and recent studies have begun to address the degree of conservation of nodal and Pitx2 in this process. Pitx2 is a member of the Pitx homeobox gene family, and in both amphioxus and ascidians Pitx gene expression is predominantly left sided. These studies suggest that left-right asymmetry in all chordates is regulated by a conserved developmental pathway, and that this pathway evolved before the separation of the lineages leading to living chordates. |
| first_indexed | 2024-03-07T05:44:10Z |
| format | Journal article |
| id | oxford-uuid:e69edc2a-888b-4c54-85a5-ad3dc84af468 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:44:10Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:e69edc2a-888b-4c54-85a5-ad3dc84af4682022-03-27T10:32:27ZThe evolution of left-right asymmetry in chordates.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e69edc2a-888b-4c54-85a5-ad3dc84af468EnglishSymplectic Elements at Oxford2002Boorman, CShimeld, SThe internal organs of all vertebrates are asymmetrically organised across the left-right axis. The development of this asymmetry is controlled by a molecular pathway that includes the signalling molecule Nodal and the transcription factor Pitx2, proteins encoded by genes that are predominantly expressed on the left side of all vertebrate embryos studied to date. Vertebrates share Phylum Chordata with two other groups of animals, amphioxus and the urochordates (including ascidians). Both these taxa develop left-right asymmetries, and recent studies have begun to address the degree of conservation of nodal and Pitx2 in this process. Pitx2 is a member of the Pitx homeobox gene family, and in both amphioxus and ascidians Pitx gene expression is predominantly left sided. These studies suggest that left-right asymmetry in all chordates is regulated by a conserved developmental pathway, and that this pathway evolved before the separation of the lineages leading to living chordates. |
| spellingShingle | Boorman, C Shimeld, S The evolution of left-right asymmetry in chordates. |
| title | The evolution of left-right asymmetry in chordates. |
| title_full | The evolution of left-right asymmetry in chordates. |
| title_fullStr | The evolution of left-right asymmetry in chordates. |
| title_full_unstemmed | The evolution of left-right asymmetry in chordates. |
| title_short | The evolution of left-right asymmetry in chordates. |
| title_sort | evolution of left right asymmetry in chordates |
| work_keys_str_mv | AT boormanc theevolutionofleftrightasymmetryinchordates AT shimelds theevolutionofleftrightasymmetryinchordates AT boormanc evolutionofleftrightasymmetryinchordates AT shimelds evolutionofleftrightasymmetryinchordates |