Deep brain stimulation for generalised dystonia and spasmodic torticollis.
Dystonia appears distinct from the other tremulous disorders in that improvement following deep brain stimulation frequently appears in a delayed and progressive manner. The rate of this improvement and the point at which no further progress can be expected are presently unknown. The establishment o...
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2005
|
| _version_ | 1826302221131710464 |
|---|---|
| author | Bittar, R Yianni, J Wang, S Liu, X Nandi, D Joint, C Scott, R Bain, P Gregory, R Stein, J Aziz, T |
| author_facet | Bittar, R Yianni, J Wang, S Liu, X Nandi, D Joint, C Scott, R Bain, P Gregory, R Stein, J Aziz, T |
| author_sort | Bittar, R |
| collection | OXFORD |
| description | Dystonia appears distinct from the other tremulous disorders in that improvement following deep brain stimulation frequently appears in a delayed and progressive manner. The rate of this improvement and the point at which no further progress can be expected are presently unknown. The establishment of these parameters is important in the provision of accurate and relevant prognostic information to these patients, their carers, and their treating physicians. We studied 12 consecutive patients with generalised dystonia (n=6) and spasmodic torticollis (n=6) who underwent bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) and were followed up for a minimum of 2 years postoperatively. Standard rating scales were used to quantify their neurological improvement. Both groups experienced a statistically significant improvement in their rating scores at both one and two years following surgery. At 2 years follow-up, the spasmodic torticollis group exhibited a 59% improvement in their total Toronto Western Spasmodic Torticoilis Rating Scale (TWSTRS) rating score and the generalised dystonia group attained a 46% improvement in their overall Burke, Fahn and Marsden Dystonia Rating Scale (BFMDRS) evaluation. Ninety-five percent of the final improvement was attained by 6.4 months in the generalised dystonia group and by 6.6 months in those with spasmodic torticollis. There was no significant improvement after one year postoperatively. These findings add further support to GPi DBS as an effective treatment for generalised dystonia and spasmodic torticollis, and furnish important information as to the expected rate of improvement and the point at which no further gains can be reasonably anticipated. |
| first_indexed | 2024-03-07T05:44:15Z |
| format | Journal article |
| id | oxford-uuid:e6a65a38-91d8-4ff0-b490-b704f1ab1eab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:44:15Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:e6a65a38-91d8-4ff0-b490-b704f1ab1eab2022-03-27T10:32:42ZDeep brain stimulation for generalised dystonia and spasmodic torticollis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e6a65a38-91d8-4ff0-b490-b704f1ab1eabEnglishSymplectic Elements at Oxford2005Bittar, RYianni, JWang, SLiu, XNandi, DJoint, CScott, RBain, PGregory, RStein, JAziz, TDystonia appears distinct from the other tremulous disorders in that improvement following deep brain stimulation frequently appears in a delayed and progressive manner. The rate of this improvement and the point at which no further progress can be expected are presently unknown. The establishment of these parameters is important in the provision of accurate and relevant prognostic information to these patients, their carers, and their treating physicians. We studied 12 consecutive patients with generalised dystonia (n=6) and spasmodic torticollis (n=6) who underwent bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) and were followed up for a minimum of 2 years postoperatively. Standard rating scales were used to quantify their neurological improvement. Both groups experienced a statistically significant improvement in their rating scores at both one and two years following surgery. At 2 years follow-up, the spasmodic torticollis group exhibited a 59% improvement in their total Toronto Western Spasmodic Torticoilis Rating Scale (TWSTRS) rating score and the generalised dystonia group attained a 46% improvement in their overall Burke, Fahn and Marsden Dystonia Rating Scale (BFMDRS) evaluation. Ninety-five percent of the final improvement was attained by 6.4 months in the generalised dystonia group and by 6.6 months in those with spasmodic torticollis. There was no significant improvement after one year postoperatively. These findings add further support to GPi DBS as an effective treatment for generalised dystonia and spasmodic torticollis, and furnish important information as to the expected rate of improvement and the point at which no further gains can be reasonably anticipated. |
| spellingShingle | Bittar, R Yianni, J Wang, S Liu, X Nandi, D Joint, C Scott, R Bain, P Gregory, R Stein, J Aziz, T Deep brain stimulation for generalised dystonia and spasmodic torticollis. |
| title | Deep brain stimulation for generalised dystonia and spasmodic torticollis. |
| title_full | Deep brain stimulation for generalised dystonia and spasmodic torticollis. |
| title_fullStr | Deep brain stimulation for generalised dystonia and spasmodic torticollis. |
| title_full_unstemmed | Deep brain stimulation for generalised dystonia and spasmodic torticollis. |
| title_short | Deep brain stimulation for generalised dystonia and spasmodic torticollis. |
| title_sort | deep brain stimulation for generalised dystonia and spasmodic torticollis |
| work_keys_str_mv | AT bittarr deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT yiannij deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT wangs deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT liux deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT nandid deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT jointc deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT scottr deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT bainp deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT gregoryr deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT steinj deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis AT azizt deepbrainstimulationforgeneraliseddystoniaandspasmodictorticollis |