Optogenetic activation of SST-positive interneurons restores hippocampal theta oscillation impairment induced by soluble amyloid beta oligomers in vivo

Abnormal accumulation of amyloid β oligomers (AβO) is a hallmark of Alzheimer's disease (AD), which leads to learning and memory deficits. Hippocampal theta oscillations that are critical in spatial navigation, learning and memory are impaired in AD. Since GABAergic interneurons, such as somato...

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Príomhchruthaitheoirí: Chung, H, Park, K, Jang, H, Kohl, M, Kwag, J
Formáid: Working paper
Foilsithe / Cruthaithe: 2018