Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

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Detalles Bibliográficos
Main Authors:	Doherty, C, Visse, R, Dinakarpandian, D, Strickland, D, Nagase, H, Troeberg, L
Formato:	Journal article
Publicado:	American Society for Biochemistry and Molecular Biology 2016

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