Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

書誌詳細
主要な著者:	Doherty, C, Visse, R, Dinakarpandian, D, Strickland, D, Nagase, H, Troeberg, L
フォーマット:	Journal article
出版事項:	American Society for Biochemistry and Molecular Biology 2016

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