Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Doherty, C, Visse, R, Dinakarpandian, D, Strickland, D, Nagase, H, Troeberg, L
Формат:	Journal article
Хэвлэсэн:	American Society for Biochemistry and Molecular Biology 2016

Ижил төстэй зүйлс

Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)
-н: Chanalaris, A, зэрэг
Хэвлэсэн: (2017)

Tissue inhibitors of metalloproteinases: evolution, structure and function.
-н: Brew, K, зэрэг
Хэвлэсэн: (2000)

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
-н: Visse, R, зэрэг
Хэвлэсэн: (2003)

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.
-н: Nagase, H, зэрэг
Хэвлэсэн: (2003)

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
-н: Yang, CY, зэрэг
Хэвлэсэн: (2020)

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
-н: C.Y. Yang, зэрэг
Хэвлэсэн: (2020-12-01)

Zymography of metalloproteinases.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2004)

Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
-н: Scilabra, S, зэрэг
Хэвлэсэн: (2013)

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.
-н: Nagase, H, зэрэг
Хэвлэсэн: (2002)

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
-н: Yamamoto, K, зэрэг
Хэвлэсэн: (2013)

Monitoring metalloproteinase activity using synthetic fluorogenic substrates.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2004)

Structure and function of matrix metalloproteinases and TIMPs.
-н: Nagase, H, зэрэг
Хэвлэсэн: (2006)

Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.
-н: Wei, S, зэрэг
Хэвлэсэн: (2003)

Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2003)

The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
-н: Brew, K, зэрэг
Хэвлэсэн: (2010)

Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase.
-н: Itoh, Y, зэрэг
Хэвлэсэн: (1995)

The interplay between JNK pathway activation, proteoglycan turnover and endocytosis in chondrocytes
-н: Ismail, H, зэрэг
Хэвлэсэн: (2017)

Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis.
-н: Jain, A, зэрэг
Хэвлэсэн: (2001)

Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity.
-н: Chung, L, зэрэг
Хэвлэсэн: (2000)

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1
-н: Nagase, H, зэрэг
Хэвлэсэн: (2000)

Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.
-н: Itoh, Y, зэрэг
Хэвлэсэн: (1995)

Steps involved in activation of the pro-matrix metalloproteinase 9 (progelatinase B)-tissue inhibitor of metalloproteinases-1 complex by 4-aminophenylmercuric acetate and proteinases.
-н: Ogata, Y, зэрэг
Хэвлэсэн: (1995)

Evidence base of pharmaconutraceuticals with chondroprotective action
-н: O. A. Shavlovskaya, зэрэг
Хэвлэсэн: (2024-04-01)

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
-н: Scilabra, S, зэрэг
Хэвлэсэн: (2016)

Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms
-н: Ronald M. Clouse, зэрэг
Хэвлэсэн: (2015-01-01)

Perspectives of chondroprotective therapy of osteoarthritis
-н: L L Alekseeva
Хэвлэсэн: (2003-08-01)

Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.
-н: Wei, S, зэрэг
Хэвлэсэн: (2005)

Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction.
-н: Pinto, A, зэрэг
Хэвлэсэн: (2006)

Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma.
-н: Ogata, Y, зэрэг
Хэвлэсэн: (2001)

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
-н: Kveiborg, M, зэрэг
Хэвлэсэн: (2010)

Matrix metalloproteinases and their inhibitors in human vitreous.
-н: De La Paz, MA, зэрэг
Хэвлэсэн: (1998)

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma
-н: Qiao Zhen-kui, зэрэг
Хэвлэсэн: (2013-01-01)

The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.
-н: Zhang, J, зэрэг
Хэвлэсэн: (2003)

Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface.
-н: Itoh, Y, зэрэг
Хэвлэсэн: (1998)

MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF MATRIX METALLOPROTEINASES DURING PREGNANCY AND DELIVERY
-н: Yu. V. Korenovsky, зэрэг
Хэвлэсэн: (2012-09-01)

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Echinoderms: Structure and Possible Functions
-н: Igor Yu. Dolmatov, зэрэг
Хэвлэсэн: (2021-09-01)

Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors.
-н: Ahonen, M, зэрэг
Хэвлэсэн: (2003)

Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors
-н: Ahonen, M, зэрэг
Хэвлэсэн: (2002)

Dexamethasone: chondroprotective corticosteroid or catabolic killer?
-н: Black, Robert Xavier, зэрэг
Хэвлэсэн: (2020)

CHONDROPROTECTIVE DRUG ALFLUTOP IN THE TREATMENT OF OSTEOARTHRITIS
-н: G V Lukina, зэрэг
Хэвлэсэн: (2001-04-01)