Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

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Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci associated with either number of children ever born (NEB) or...

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Príomhchruthaitheoirí: Mathieson, I, Day, FR, Barban, N, Tropf, FC, Brazel, DM, eQTLGen Consortium, BIOS Consortium, Vaez, A, van Zuydam, N, Bitarello, BD, Gardner, EJ, Akimova, ET, Azad, A, Bergmann, S, Bielak, LF, Boomsma, DI, Bosak, K, Brumat, M, Buring, JE, Cesarini, D, Chasman, DI, Chavarro, JE, Cocca, M, Concas, MP, Davey Smith, G, Davies, G, Deary, IJ, Esko, T, Faul, JD, FinnGen Study, Franco, O, Ganna, A, Gaskins, AJ, Gelemanovic, A, de Geus, EJC, Gieger, C, Girotto, G, Gopinath, B, Grabe, HJ, Gunderson, EP, Hayward, C, He, C, van Heemst, D, Hill, WD, Hoffmann, ER, Homuth, G, Hottenga, JJ, Huang, H, Hyppӧnen, E, Ikram, MA, Mills, MC
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Springer Nature 2023

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