ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart

Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of...

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Bibliographic Details
Main Authors: Lewis, A, Aley, P, Roomi, A, Thomas, J, Masgrau, R, Garnham, C, Shipman, K, Paramore, C, Bloor-Young, D, Sanders, L, Terrar, D, Galione, A, Churchill, G
Format: Journal article
Language:English
Published: 2012
Description
Summary:Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts ß-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the ß-adrenergic receptor signaling pathway. © 2012 Elsevier Inc.