ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart
Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826302244804362240 |
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| author | Lewis, A Aley, P Roomi, A Thomas, J Masgrau, R Garnham, C Shipman, K Paramore, C Bloor-Young, D Sanders, L Terrar, D Galione, A Churchill, G |
| author_facet | Lewis, A Aley, P Roomi, A Thomas, J Masgrau, R Garnham, C Shipman, K Paramore, C Bloor-Young, D Sanders, L Terrar, D Galione, A Churchill, G |
| author_sort | Lewis, A |
| collection | OXFORD |
| description | Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts ß-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the ß-adrenergic receptor signaling pathway. © 2012 Elsevier Inc. |
| first_indexed | 2024-03-07T05:44:37Z |
| format | Journal article |
| id | oxford-uuid:e6c8a227-6465-495d-b5d1-3d7ff51aecb4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:44:37Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:e6c8a227-6465-495d-b5d1-3d7ff51aecb42022-03-27T10:33:33Zß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heartJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e6c8a227-6465-495d-b5d1-3d7ff51aecb4EnglishSymplectic Elements at Oxford2012Lewis, AAley, PRoomi, AThomas, JMasgrau, RGarnham, CShipman, KParamore, CBloor-Young, DSanders, LTerrar, DGalione, AChurchill, GEvidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts ß-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the ß-adrenergic receptor signaling pathway. © 2012 Elsevier Inc. |
| spellingShingle | Lewis, A Aley, P Roomi, A Thomas, J Masgrau, R Garnham, C Shipman, K Paramore, C Bloor-Young, D Sanders, L Terrar, D Galione, A Churchill, G ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart |
| title | ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart |
| title_full | ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart |
| title_fullStr | ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart |
| title_full_unstemmed | ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart |
| title_short | ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart |
| title_sort | ss adrenergic receptor signaling increases naadp and cadpr levels in the heart |
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