Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.
Vaccinia infection interferes with the presentation of influenza Haemagglutinin (HA) and Nucleoprotein (NP) to class I-restricted CTL. The inhibitory effect is selective for certain epitopes, and is more profound during the late phase of infection. For influenza A/NT/60/68 NP, the block is present d...
Prif Awduron: | Townsend, A, Bastin, J, Gould, K, Brownlee, G, Andrew, M, Coupar, B, Boyle, D, Chan, S, Smith, G |
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Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
1988
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Eitemau Tebyg
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Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes.
gan: Blake, N, et al.
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A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes.
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DO VACCINIA VIRUS-ENCODED SERPINS INHIBIT ANTIGEN PRESENTATION TO CLASS I-RESTRICTED CTL
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Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence
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Mouse H-2(k)-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin
gan: Gould, K, et al.
Cyhoeddwyd: (1987)