O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes.
O'nyong-nyong (ONN) fever, caused by infection with a mosquito-borne central African alphavirus, is an acute, nonfatal illness characterized by polyarthralgia. During 1996-1997, south-central Uganda experienced the second ONN fever epidemic ever recognized. Among 391 persons interviewed and sam...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797100941724352512 |
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| author | Kiwanuka, N Sanders, E Rwaguma, E Kawamata, J Ssengooba, F Najjemba, R Were, W Lamunu, M Bagambisa, G Burkot, T Dunster, L Lutwama, J Martin, D Cropp, C Karabatsos, N Lanciotti, R Tsai, T Campbell, G |
| author_facet | Kiwanuka, N Sanders, E Rwaguma, E Kawamata, J Ssengooba, F Najjemba, R Were, W Lamunu, M Bagambisa, G Burkot, T Dunster, L Lutwama, J Martin, D Cropp, C Karabatsos, N Lanciotti, R Tsai, T Campbell, G |
| author_sort | Kiwanuka, N |
| collection | OXFORD |
| description | O'nyong-nyong (ONN) fever, caused by infection with a mosquito-borne central African alphavirus, is an acute, nonfatal illness characterized by polyarthralgia. During 1996-1997, south-central Uganda experienced the second ONN fever epidemic ever recognized. Among 391 persons interviewed and sampled, 40 cases of confirmed and 21 of presumptive, well-characterized acute, recent, or previous ONN fever were identified through active case-finding efforts or during a household serosurvey and by the application of clinical and laboratory criteria. Among confirmed cases, the knees and ankles were the joints most commonly affected. The median duration of arthralgia was 6 days (range, 2-21 days) and of immobilization was 4 days (range, 1-14 days). In the majority, generalized skin rash was reported, and nearly half had lymphadenopathy, mainly of the cervical region. Viremia was documented in 16 cases, primarily during the first 3 days of illness, and in some of these, body temperature was normal. During this epidemic, the combination of fever, arthralgia, and lymphadenopathy had a specificity of 83% and a sensitivity of 61% in the identification of cases of ONN fever and thus could be useful for surveillance purposes. |
| first_indexed | 2024-03-07T05:44:52Z |
| format | Journal article |
| id | oxford-uuid:e6e294f0-0f81-4f2c-9206-778597d86e5e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:44:52Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:e6e294f0-0f81-4f2c-9206-778597d86e5e2022-03-27T10:34:12ZO'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e6e294f0-0f81-4f2c-9206-778597d86e5eEnglishSymplectic Elements at Oxford1999Kiwanuka, NSanders, ERwaguma, EKawamata, JSsengooba, FNajjemba, RWere, WLamunu, MBagambisa, GBurkot, TDunster, LLutwama, JMartin, DCropp, CKarabatsos, NLanciotti, RTsai, TCampbell, GO'nyong-nyong (ONN) fever, caused by infection with a mosquito-borne central African alphavirus, is an acute, nonfatal illness characterized by polyarthralgia. During 1996-1997, south-central Uganda experienced the second ONN fever epidemic ever recognized. Among 391 persons interviewed and sampled, 40 cases of confirmed and 21 of presumptive, well-characterized acute, recent, or previous ONN fever were identified through active case-finding efforts or during a household serosurvey and by the application of clinical and laboratory criteria. Among confirmed cases, the knees and ankles were the joints most commonly affected. The median duration of arthralgia was 6 days (range, 2-21 days) and of immobilization was 4 days (range, 1-14 days). In the majority, generalized skin rash was reported, and nearly half had lymphadenopathy, mainly of the cervical region. Viremia was documented in 16 cases, primarily during the first 3 days of illness, and in some of these, body temperature was normal. During this epidemic, the combination of fever, arthralgia, and lymphadenopathy had a specificity of 83% and a sensitivity of 61% in the identification of cases of ONN fever and thus could be useful for surveillance purposes. |
| spellingShingle | Kiwanuka, N Sanders, E Rwaguma, E Kawamata, J Ssengooba, F Najjemba, R Were, W Lamunu, M Bagambisa, G Burkot, T Dunster, L Lutwama, J Martin, D Cropp, C Karabatsos, N Lanciotti, R Tsai, T Campbell, G O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. |
| title | O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. |
| title_full | O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. |
| title_fullStr | O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. |
| title_full_unstemmed | O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. |
| title_short | O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. |
| title_sort | o nyong nyong fever in south central uganda 1996 1997 clinical features and validation of a clinical case definition for surveillance purposes |
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