The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage
Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon...
Main Authors: | Nishi, R, Wijnhoven, P, Kimura, Y, Matsui, M, Konietzny, R, Wu, Q, Nakamura, K, Blundell, T, Kessler, B |
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Format: | Journal article |
Language: | English |
Published: |
Springer Nature Publishing Group
2018
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