HIV T cell vaccines, the importance of clades.
Development of an HIV vaccine presents a formidable challenge. One of the unresolved, yet central issues is the importance of HIV variability. Here we argue that even with the recent focus on the induction of T cell-mediated immunity, HIV vaccines should match the local circulating HIV clades. Wheth...
| Autori principali: | , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
2002
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| _version_ | 1826302270242816000 |
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| author | McMichael, A Mwau, M Hanke, T |
| author_facet | McMichael, A Mwau, M Hanke, T |
| author_sort | McMichael, A |
| collection | OXFORD |
| description | Development of an HIV vaccine presents a formidable challenge. One of the unresolved, yet central issues is the importance of HIV variability. Here we argue that even with the recent focus on the induction of T cell-mediated immunity, HIV vaccines should match the local circulating HIV clades. Whether used alone or in a combination with vaccines eliciting HIV-neutralizing antibodies, efforts must be made to develop a T cell vaccine that stimulates a broad and long-lasting response. |
| first_indexed | 2024-03-07T05:45:01Z |
| format | Journal article |
| id | oxford-uuid:e6ee2587-cebd-4360-8a01-9ab4801be750 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:45:01Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:e6ee2587-cebd-4360-8a01-9ab4801be7502022-03-27T10:34:36ZHIV T cell vaccines, the importance of clades.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e6ee2587-cebd-4360-8a01-9ab4801be750EnglishSymplectic Elements at Oxford2002McMichael, AMwau, MHanke, TDevelopment of an HIV vaccine presents a formidable challenge. One of the unresolved, yet central issues is the importance of HIV variability. Here we argue that even with the recent focus on the induction of T cell-mediated immunity, HIV vaccines should match the local circulating HIV clades. Whether used alone or in a combination with vaccines eliciting HIV-neutralizing antibodies, efforts must be made to develop a T cell vaccine that stimulates a broad and long-lasting response. |
| spellingShingle | McMichael, A Mwau, M Hanke, T HIV T cell vaccines, the importance of clades. |
| title | HIV T cell vaccines, the importance of clades. |
| title_full | HIV T cell vaccines, the importance of clades. |
| title_fullStr | HIV T cell vaccines, the importance of clades. |
| title_full_unstemmed | HIV T cell vaccines, the importance of clades. |
| title_short | HIV T cell vaccines, the importance of clades. |
| title_sort | hiv t cell vaccines the importance of clades |
| work_keys_str_mv | AT mcmichaela hivtcellvaccinestheimportanceofclades AT mwaum hivtcellvaccinestheimportanceofclades AT hanket hivtcellvaccinestheimportanceofclades |