Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.

Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.

KirBac1.1 and 3.1 are bacterial homologues of mammalian inward rectifier K channels. We have performed extended molecular dynamics simulations (five simulations, each of >20 ns duration) of the transmembrane domain of KirBac in two membrane environments, a palmitoyl oleoyl phosphatidylcholine...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Grottesi, A, Domene, C, Hall, B, Sansom, MS
التنسيق:	Journal article
اللغة:	English
منشور في:	2005

مواد مشابهة

Permeation and gating in KirBac: Molecular dynamics simulations
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منشور في: (2004)

Investigating open pore structure: Essential dynamics sampling of motions performed by the inner S6 helix bundle in KirBac.
حسب: Grottesi, A, وآخرون
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Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
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Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.
حسب: Zubcevic, L, وآخرون
منشور في: (2014)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
حسب: Kuo, A, وآخرون
منشور في: (2005)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
حسب: Kuo, A, وآخرون
منشور في: (2005)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
حسب: Bavro, V, وآخرون
منشور في: (2012)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
حسب: Bavro, V, وآخرون
منشور في: (2012)

Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.
حسب: Paynter, J, وآخرون
منشور في: (2010)

Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy.
حسب: Jarosławski, S, وآخرون
منشور في: (2007)

Functional complementation and genetic deletion studies of KirBac channels: Activatory mutations highlight gating-sensitive domains
حسب: Paynter, J, وآخرون
منشور في: (2010)

Crystal structure of the potassium channel KirBac1.1 in the closed state.
حسب: Kuo, A, وآخرون
منشور في: (2003)

Single-molecule fluorescence studies of KirBac1.1
حسب: Sadler, E, وآخرون
منشور في: (2015)

Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.
حسب: Haider, S, وآخرون
منشور في: (2005)

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
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The open state of KirBac3.1 observed by cryo-electron microscopy
حسب: Zadek, B, وآخرون
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Molecular dynamics simulation of open and close confirmations of KirBac1.1 in explicit lipid billayer: Structural changes and aromatic localization at lipid/water interface
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Codon Harmonization of a Kir3.1-KirBac1.3 Chimera for Structural Study Optimization
حسب: Evan Van Aalst, وآخرون
منشور في: (2020-03-01)

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.
حسب: Rapedius, M, وآخرون
منشور في: (2007)

Identification of gain of function mutations in KirBac potassium channels by genetic complementation in K+ auxotrophic strains of E-coli and yeast.
حسب: Paynter, J, وآخرون
منشور في: (2007)

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
حسب: Rapedius, M, وآخرون
منشور في: (2007)

The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.
حسب: Sands, Z, وآخرون
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Conformational dynamics of helix S6 from Shaker potassium channel: simulation studies.
حسب: Bright, J, وآخرون
منشور في: (2002)

Voltage-gated ion channels.
حسب: Sands, Z, وآخرون
منشور في: (2005)

Conformational rearrangements during PIP2 gating in Kir channels
حسب: Rapedius, M, وآخرون
منشور في: (2007)

The role of extra-membranous inter-helical loops in helix-helix interactions.
حسب: Ulmschneider, M, وآخرون
منشور في: (2005)

Ion channel gating: insights via molecular simulations.
حسب: Beckstein, O, وآخرون
منشور في: (2003)

Ion channel gates: comparative analysis of energy barriers.
حسب: Tai, K, وآخرون
منشور في: (2009)

Insights into the structural nature of the transition state in the Kir channel gating pathway.
حسب: Fowler, P, وآخرون
منشور في: (2014)

Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel
حسب: Lacin, E, وآخرون
منشور في: (2017)

Helix dynamics in a membrane transport protein: comparative simulations of the glycerol-3-phosphate transporter and its constituent helices.
حسب: D'Rozario, R, وآخرون
منشور في: (2008)

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
حسب: Haider, S, وآخرون
منشور في: (2007)

Molecular dynamics simulations of a K+ channel blocker: Tc1 toxin from Tityus cambridgei.
حسب: Grottesi, A, وآخرون
منشور في: (2003)

Crystal Structure of a Prokaryotic Kir Channel in an Open Conformation
حسب: Bavro, V, وآخرون
منشور في: (2012)

Proline associated conformational changes in the S6 helix of Kv channels
حسب: Bright, J, وآخرون
منشور في: (2002)

Molecular dynamics simulations and KcsA channel gating.
حسب: Shrivastava, I, وآخرون
منشور في: (2002)

Gating at both ends and breathing in the middle: conformational dynamics of TolC.
حسب: Vaccaro, L, وآخرون
منشور في: (2008)

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
حسب: Capener, C, وآخرون
منشور في: (2003)

Proline-induced hinges in transmembrane helices: possible roles in ion channel gating.
حسب: Tieleman, D, وآخرون
منشور في: (2001)

The flexing/twirling helix: Exploring the flexibility about molecular hinges formed by proline and glycine motifs in transmembrane helices
حسب: Bright, J, وآخرون
منشور في: (2003)