The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.

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Dyslexia is one of the most prevalent childhood cognitive disorders, affecting approximately 5% of school-age children. We have recently identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319. Here we show that in the p...

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Príomhchruthaitheoirí:	Paracchini, S, Thomas, A, Castro, S, Lai, C, Paramasivam, M, Wang, Y, Keating, B, Taylor, J, Hacking, D, Scerri, T, Francks, C, Richardson, A, Wade-Martins, R, Stein, J, Knight, J, Copp, A, Loturco, J, Monaco, A
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2006

Míreanna comhchosúla

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
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Foilsithe / Cruthaithe: (2006)

Expression of the KIAA0319 gene from a haplotype associated with developmental dyslexia
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A common variant associated with dyslexia reduces expression of the KIAA0319 gene.
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Alternative splicing in the dyslexia-associated gene KIAA0319.
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Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
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A common variant associated with dyslexia reduces expression of the KIAA0319 gene.
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Linkage disequilibrium structure of KIAA0319 and DCDC2, two candidate susceptibility genes for developmental dyslexia
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The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms.
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Knockout mice for dyslexia susceptibility gene homologs KIAA0319 and KIAA0319L have unaffected neuronal migration but display abnormal auditory processing
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DCDC2, KIAA0319 and CMIP are associated with reading-related traits
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DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
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The Dyslexia-susceptibility protein KIAA0319 inhibits axon growth through Smad2 signaling.
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The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage.
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The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway.
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PCSK6 is associated with handedness in individuals with dyslexia.
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A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.
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Characterisation of a major locus for developmental dyslexia on 18p11.2.
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