Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM.
'Checkpoint' controls arrest the cell cycle after DNA damage, allowing repair to take place before mutations can be perpetuated. In multicellular organisms, DNA damage can also induce apoptotic cell death, protecting the organism at the expense of the individual cell. How does a cell '...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1797101019652423680 |
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| author | Enoch, T Norbury, C |
| author_facet | Enoch, T Norbury, C |
| author_sort | Enoch, T |
| collection | OXFORD |
| description | 'Checkpoint' controls arrest the cell cycle after DNA damage, allowing repair to take place before mutations can be perpetuated. In multicellular organisms, DNA damage can also induce apoptotic cell death, protecting the organism at the expense of the individual cell. How does a cell 'choose' between cycle arrest and death? Analysis of two human tumour suppressor proteins, p53 and the ATM (ataxia-telangiectasia mutated) gene product, may provide some answers. |
| first_indexed | 2024-03-07T05:45:57Z |
| format | Journal article |
| id | oxford-uuid:e7389da6-5b6c-40dd-b671-b36b00462ae9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:45:57Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:e7389da6-5b6c-40dd-b671-b36b00462ae92022-03-27T10:36:55ZCellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e7389da6-5b6c-40dd-b671-b36b00462ae9EnglishSymplectic Elements at Oxford1995Enoch, TNorbury, C'Checkpoint' controls arrest the cell cycle after DNA damage, allowing repair to take place before mutations can be perpetuated. In multicellular organisms, DNA damage can also induce apoptotic cell death, protecting the organism at the expense of the individual cell. How does a cell 'choose' between cycle arrest and death? Analysis of two human tumour suppressor proteins, p53 and the ATM (ataxia-telangiectasia mutated) gene product, may provide some answers. |
| spellingShingle | Enoch, T Norbury, C Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. |
| title | Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. |
| title_full | Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. |
| title_fullStr | Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. |
| title_full_unstemmed | Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. |
| title_short | Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. |
| title_sort | cellular responses to dna damage cell cycle checkpoints apoptosis and the roles of p53 and atm |
| work_keys_str_mv | AT enocht cellularresponsestodnadamagecellcyclecheckpointsapoptosisandtherolesofp53andatm AT norburyc cellularresponsestodnadamagecellcyclecheckpointsapoptosisandtherolesofp53andatm |