global sensitivity tool for cardiac cell modeling: Application to ionic current balance and hypertrophic signaling

global sensitivity tool for cardiac cell modeling: Application to ionic current balance and hypertrophic signaling

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Cardiovascular diseases are the major cause of death in the developed countries. Identifying key cellular processes involved in generation of the electrical signal and in regulation of signal transduction pathways is essential for unraveling the underlying mechanisms of heart rhythm behavior. Comput...

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Detaylı Bibliyografya
Asıl Yazarlar: Sher, A, Cooling, M, Bethwaite, B, Tan, J, Peachey, T, Enticott, C, Garic, S, Gavaghan, D, Noble, D, Abramson, D, Crampin, E
Materyal Türü: Journal article
Baskı/Yayın Bilgisi: 2010
Diğer Bilgiler
Özet:Cardiovascular diseases are the major cause of death in the developed countries. Identifying key cellular processes involved in generation of the electrical signal and in regulation of signal transduction pathways is essential for unraveling the underlying mechanisms of heart rhythm behavior. Computational cardiac models provide important insights into cardiovascular function and disease. Sensitivity analysis presents a key tool for exploring the large parameter space of such models, in order to determine the key factors determining and controlling the underlying p

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