Genetic diversity and dynamics of Plasmodium falciparum and P. vivax populations in multiply infected children with asymptomatic malaria infections in Papua New Guinea
We describe the dynamics of co-infections of Plasmodium falciparum and P. vivax in 28 asymptomatic children by genotyping these species using the polymorphic loci Msp2 and Msp3a, respectively. The total number of Plasmodium spp. infections detected using 3 day sampling over 61 days varied between 1...
| Format: | Journal article |
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Cambridge University Press
2000
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| _version_ | 1826302352873750528 |
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| collection | OXFORD |
| description | We describe the dynamics of co-infections of Plasmodium falciparum and P. vivax in 28 asymptomatic children by genotyping these species using the polymorphic loci Msp2 and Msp3a, respectively. The total number of Plasmodium spp. infections detected using 3 day sampling over 61 days varied between 1 and 14 (mean 6±6). The dynamics of P. falciparum and P. vivax genotypes varied greatly both within and amongst children. Periodicity in the detection of P. falciparum infections is consistent with the synchronous replication of individual genotypes. Replication synchrony of multiple coinfecting genotypes was not detected. In 4-year-old children P. falciparum genotype complexity was reduced and episodes lasted signi®cantly longer (median duration"60 days) when compared to children aged 5±14 years (median duration 9 days). P. vivax genotype complexity was not correlated with age but the episode duration was also longer for this species in 4-year-olds than in older children but was not as long as P. falciparum episodes. Recurrence of P. falciparum and P. vivax genotypes over weeks was observed. We interpret these major ¯uctuations in the density of genotypes over time as the result of the mechanism of antigenic variation thought to be present in these Plasmodium species. |
| first_indexed | 2024-03-07T05:46:16Z |
| format | Journal article |
| id | oxford-uuid:e755a04c-3aab-40da-9bef-d46f1f31f48d |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:46:16Z |
| publishDate | 2000 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oxford-uuid:e755a04c-3aab-40da-9bef-d46f1f31f48d2022-03-27T10:37:45ZGenetic diversity and dynamics of Plasmodium falciparum and P. vivax populations in multiply infected children with asymptomatic malaria infections in Papua New GuineaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e755a04c-3aab-40da-9bef-d46f1f31f48dZoology (including the Institute of Biological Anthropology)Oxford University Research Archive - ValetCambridge University Press2000We describe the dynamics of co-infections of Plasmodium falciparum and P. vivax in 28 asymptomatic children by genotyping these species using the polymorphic loci Msp2 and Msp3a, respectively. The total number of Plasmodium spp. infections detected using 3 day sampling over 61 days varied between 1 and 14 (mean 6±6). The dynamics of P. falciparum and P. vivax genotypes varied greatly both within and amongst children. Periodicity in the detection of P. falciparum infections is consistent with the synchronous replication of individual genotypes. Replication synchrony of multiple coinfecting genotypes was not detected. In 4-year-old children P. falciparum genotype complexity was reduced and episodes lasted signi®cantly longer (median duration"60 days) when compared to children aged 5±14 years (median duration 9 days). P. vivax genotype complexity was not correlated with age but the episode duration was also longer for this species in 4-year-olds than in older children but was not as long as P. falciparum episodes. Recurrence of P. falciparum and P. vivax genotypes over weeks was observed. We interpret these major ¯uctuations in the density of genotypes over time as the result of the mechanism of antigenic variation thought to be present in these Plasmodium species. |
| spellingShingle | Zoology (including the Institute of Biological Anthropology) Genetic diversity and dynamics of Plasmodium falciparum and P. vivax populations in multiply infected children with asymptomatic malaria infections in Papua New Guinea |
| title | Genetic diversity and dynamics of Plasmodium falciparum
and P. vivax populations in multiply infected
children with asymptomatic malaria infections
in Papua New Guinea |
| title_full | Genetic diversity and dynamics of Plasmodium falciparum
and P. vivax populations in multiply infected
children with asymptomatic malaria infections
in Papua New Guinea |
| title_fullStr | Genetic diversity and dynamics of Plasmodium falciparum
and P. vivax populations in multiply infected
children with asymptomatic malaria infections
in Papua New Guinea |
| title_full_unstemmed | Genetic diversity and dynamics of Plasmodium falciparum
and P. vivax populations in multiply infected
children with asymptomatic malaria infections
in Papua New Guinea |
| title_short | Genetic diversity and dynamics of Plasmodium falciparum
and P. vivax populations in multiply infected
children with asymptomatic malaria infections
in Papua New Guinea |
| title_sort | genetic diversity and dynamics of plasmodium falciparum and p vivax populations in multiply infected children with asymptomatic malaria infections in papua new guinea |
| topic | Zoology (including the Institute of Biological Anthropology) |