Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia
<strong>Background</strong> The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries. <br> <strong>Methods</strong>...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1797101054982094848 |
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| author | Singh, SR Mao, B Evdokimov, K Tan, P Leab, P Ong, R Vonthanak, S Tam, CC Hsu, LY Turner, P |
| author_facet | Singh, SR Mao, B Evdokimov, K Tan, P Leab, P Ong, R Vonthanak, S Tam, CC Hsu, LY Turner, P |
| author_sort | Singh, SR |
| collection | OXFORD |
| description | <strong>Background</strong>
The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries.
<br>
<strong>Methods</strong>
We conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage.
<br>
<strong>Results</strong>
Forty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts.
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<strong>Conclusions</strong>
The high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread. |
| first_indexed | 2024-03-07T05:46:29Z |
| format | Journal article |
| id | oxford-uuid:e765d01b-598f-4071-92c6-1d81ce249797 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:46:29Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:e765d01b-598f-4071-92c6-1d81ce2497972022-03-27T10:38:23ZPrevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, CambodiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e765d01b-598f-4071-92c6-1d81ce249797EnglishSymplectic ElementsOxford University Press2020Singh, SRMao, BEvdokimov, KTan, PLeab, POng, RVonthanak, STam, CCHsu, LYTurner, P<strong>Background</strong> The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries. <br> <strong>Methods</strong> We conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage. <br> <strong>Results</strong> Forty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts. <br> <strong>Conclusions</strong> The high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread. |
| spellingShingle | Singh, SR Mao, B Evdokimov, K Tan, P Leab, P Ong, R Vonthanak, S Tam, CC Hsu, LY Turner, P Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia |
| title | Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia |
| title_full | Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia |
| title_fullStr | Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia |
| title_full_unstemmed | Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia |
| title_short | Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia |
| title_sort | prevalence of mdr organism mdro carriage in children and their household members in siem reap province cambodia |
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