Diffusive drug delivery in the brain extracellular space from a cellular scale microtube
The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs d...
| 主要な著者: | , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
Springer Nature
2022
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| _version_ | 1826310042999062528 |
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| author | Störi, M-J Oluwasanya, PW Proctor, CM |
| author_facet | Störi, M-J Oluwasanya, PW Proctor, CM |
| author_sort | Störi, M-J |
| collection | OXFORD |
| description | The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. The influence of flow rate, drug properties and device geometry are investigated. It is anticipated that these findings will accelerate progress on both developmental and applied drug delivery and materials research. |
| first_indexed | 2024-03-07T07:44:40Z |
| format | Journal article |
| id | oxford-uuid:e76f21d6-b8a9-4f50-a8dd-6e9c66c1fcb8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:44:40Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:e76f21d6-b8a9-4f50-a8dd-6e9c66c1fcb82023-05-25T11:33:52ZDiffusive drug delivery in the brain extracellular space from a cellular scale microtubeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e76f21d6-b8a9-4f50-a8dd-6e9c66c1fcb8EnglishSymplectic ElementsSpringer Nature2022Störi, M-JOluwasanya, PWProctor, CMThe effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. The influence of flow rate, drug properties and device geometry are investigated. It is anticipated that these findings will accelerate progress on both developmental and applied drug delivery and materials research. |
| spellingShingle | Störi, M-J Oluwasanya, PW Proctor, CM Diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| title | Diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| title_full | Diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| title_fullStr | Diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| title_full_unstemmed | Diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| title_short | Diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| title_sort | diffusive drug delivery in the brain extracellular space from a cellular scale microtube |
| work_keys_str_mv | AT storimj diffusivedrugdeliveryinthebrainextracellularspacefromacellularscalemicrotube AT oluwasanyapw diffusivedrugdeliveryinthebrainextracellularspacefromacellularscalemicrotube AT proctorcm diffusivedrugdeliveryinthebrainextracellularspacefromacellularscalemicrotube |