Vinyl Weinreb amides: A versatile alternative to vinyl ketone substrates for the Heck arylation

This paper describes the use of unsaturated Weinreb amides as excellent substrates for the Heck reaction. Subsequent derivatization of the products with organometallic reagents allowed access to a variety of substituted vinyl ketones that could not have been prepared directly via Heck reaction on un...

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Bibliographic Details
Main Authors: Baker, D, Gallagher, P, Donohoe, T
Format: Journal article
Language:English
Published: 2013
Description
Summary:This paper describes the use of unsaturated Weinreb amides as excellent substrates for the Heck reaction. Subsequent derivatization of the products with organometallic reagents allowed access to a variety of substituted vinyl ketones that could not have been prepared directly via Heck reaction on unsaturated ketone precursors. © 2013 Elsevier Ltd. All rights reserved.