Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation.
Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1826302411872927744 |
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| author | Parsy, M Harlos, K Huiskonen, J Bowden, T |
| author_facet | Parsy, M Harlos, K Huiskonen, J Bowden, T |
| author_sort | Parsy, M |
| collection | OXFORD |
| description | Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion. |
| first_indexed | 2024-03-07T05:47:09Z |
| format | Journal article |
| id | oxford-uuid:e7996f12-6b94-4a7a-a823-cabac1b59a5f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:47:09Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:e7996f12-6b94-4a7a-a823-cabac1b59a5f2022-03-27T10:40:02ZCrystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e7996f12-6b94-4a7a-a823-cabac1b59a5fEnglishSymplectic Elements at Oxford2013Parsy, MHarlos, KHuiskonen, JBowden, TGuanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion. |
| spellingShingle | Parsy, M Harlos, K Huiskonen, J Bowden, T Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation. |
| title | Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation. |
| title_full | Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation. |
| title_fullStr | Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation. |
| title_full_unstemmed | Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation. |
| title_short | Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation. |
| title_sort | crystal structure of venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation |
| work_keys_str_mv | AT parsym crystalstructureofvenezuelanhemorrhagicfevervirusfusionglycoproteinrevealsaclass1postfusionarchitecturewithextensiveglycosylation AT harlosk crystalstructureofvenezuelanhemorrhagicfevervirusfusionglycoproteinrevealsaclass1postfusionarchitecturewithextensiveglycosylation AT huiskonenj crystalstructureofvenezuelanhemorrhagicfevervirusfusionglycoproteinrevealsaclass1postfusionarchitecturewithextensiveglycosylation AT bowdent crystalstructureofvenezuelanhemorrhagicfevervirusfusionglycoproteinrevealsaclass1postfusionarchitecturewithextensiveglycosylation |