Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.
The adaptor protein Grb2 links cell-surface receptors, such as Her2, to the multisite docking proteins Gab1 and 2, leading to cell growth and proliferation in breast and other cancers. Gab2 interacts with the C-terminal SH3 domain (SH3C) of Grb2 through atypical RxxK motifs within polyproline II or...
| Główni autorzy: | , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2013
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