Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients
Recent results have shown a correlation between survival and frequency of tumour infiltrating T lymphocytes in colorectal cancer patients. However, it remains unclear whether the frequency of regulatory T cells is higher in colorectal cancer as compared to normal colon. To address this question we a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1826302430687526912 |
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| author | Khoon, L Pratap, SE Bates, G Singh, B Mortensen, N George, B Warren, B Piris, J Roncador, G Fox, S Banham, A Cerundolo, V |
| author_facet | Khoon, L Pratap, SE Bates, G Singh, B Mortensen, N George, B Warren, B Piris, J Roncador, G Fox, S Banham, A Cerundolo, V |
| author_sort | Khoon, L |
| collection | OXFORD |
| description | Recent results have shown a correlation between survival and frequency of tumour infiltrating T lymphocytes in colorectal cancer patients. However, it remains unclear whether the frequency of regulatory T cells is higher in colorectal cancer as compared to normal colon. To address this question we analysed the frequency and function of regulatory T cells in the peripheral blood and tumour infiltrating lymphocytes of colorectal cancer patients. The proportion of regulatory T cells in the peripheral blood of colorectal cancer patients (mean 8%) was significantly higher than that in normal controls (mean 2.2%). There were significantly more regulatory T cells in tumour infiltrating lymphocytes (mean 19.2%) compared to lymphocytes from an autologous non-malignant portion of the colon (mean 9%). Regulatory T cells from colorectal cancer patients were FOXP3 positive and suppressed the proliferation of autologous CD4+ CD25- cells. A higher density of tumour infiltrating regulatory T cells was found in patients with advanced as compared to early disease. These results support the hypothesis that increased numbers of regulatory T cells in the blood and tumours of colorectal cancer patients may influence the immune response against cancer and suggest that strategies to overcome regulatory T cell activity may be beneficial in the treatment of human colorectal cancer. Copyright © 2007 by Vincenzo Cerundolo. |
| first_indexed | 2024-03-07T05:47:26Z |
| format | Journal article |
| id | oxford-uuid:e7aff1a6-b15c-4864-89b8-a3da3f0436af |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:47:26Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:e7aff1a6-b15c-4864-89b8-a3da3f0436af2022-03-27T10:40:51ZIncreased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e7aff1a6-b15c-4864-89b8-a3da3f0436afEnglishSymplectic Elements at Oxford2007Khoon, LPratap, SEBates, GSingh, BMortensen, NGeorge, BWarren, BPiris, JRoncador, GFox, SBanham, ACerundolo, VRecent results have shown a correlation between survival and frequency of tumour infiltrating T lymphocytes in colorectal cancer patients. However, it remains unclear whether the frequency of regulatory T cells is higher in colorectal cancer as compared to normal colon. To address this question we analysed the frequency and function of regulatory T cells in the peripheral blood and tumour infiltrating lymphocytes of colorectal cancer patients. The proportion of regulatory T cells in the peripheral blood of colorectal cancer patients (mean 8%) was significantly higher than that in normal controls (mean 2.2%). There were significantly more regulatory T cells in tumour infiltrating lymphocytes (mean 19.2%) compared to lymphocytes from an autologous non-malignant portion of the colon (mean 9%). Regulatory T cells from colorectal cancer patients were FOXP3 positive and suppressed the proliferation of autologous CD4+ CD25- cells. A higher density of tumour infiltrating regulatory T cells was found in patients with advanced as compared to early disease. These results support the hypothesis that increased numbers of regulatory T cells in the blood and tumours of colorectal cancer patients may influence the immune response against cancer and suggest that strategies to overcome regulatory T cell activity may be beneficial in the treatment of human colorectal cancer. Copyright © 2007 by Vincenzo Cerundolo. |
| spellingShingle | Khoon, L Pratap, SE Bates, G Singh, B Mortensen, N George, B Warren, B Piris, J Roncador, G Fox, S Banham, A Cerundolo, V Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
| title | Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
| title_full | Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
| title_fullStr | Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
| title_full_unstemmed | Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
| title_short | Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
| title_sort | increased frequency of regulatory t cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients |
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