Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated in the rat P22 tumor growing in a dorsal skin flap window chamber implanted into BD9 rats. CA-4-P is in clinical trial as a tumor vascular targeting agent. In animal tumo...

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Hlavní autoři: Tozer, G, Prise, V, Wilson, J, Cemazar, M, Shan, S, Dewhirst, M, Barber, P, Vojnovic, B, Chaplin, D
Médium: Journal article
Jazyk:English
Vydáno: 2001