A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.

A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.

The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with 11 haplotype tagging-polymorphisms...

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Detalhes bibliográficos
Main Authors: Diakite, M, Clark, T, Auburn, S, Campino, S, Fry, A, Green, A, Morris, A, Richardson, A, Jallow, M, Sisay-Joof, F, Pinder, M, Kwiatkowski, D, Rockett, K
Formato: Journal article
Idioma:English
Publicado em: 2009

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