Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.

The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in women with suspected preeclampsia is unclear.We performed a prospective, multicenter, observational study to...

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প্রধান লেখক: Zeisler, H, Llurba, E, Chantraine, F, Vatish, M, Staff, A, Sennström, M, Olovsson, M, Brennecke, S, Stepan, H, Allegranza, D, Dilba, P, Schoedl, M, Hund, M, Verlohren, S
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2016
_version_ 1826302448785948672
author Zeisler, H
Llurba, E
Chantraine, F
Vatish, M
Staff, A
Sennström, M
Olovsson, M
Brennecke, S
Stepan, H
Allegranza, D
Dilba, P
Schoedl, M
Hund, M
Verlohren, S
author_facet Zeisler, H
Llurba, E
Chantraine, F
Vatish, M
Staff, A
Sennström, M
Olovsson, M
Brennecke, S
Stepan, H
Allegranza, D
Dilba, P
Schoedl, M
Hund, M
Verlohren, S
author_sort Zeisler, H
collection OXFORD
description The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in women with suspected preeclampsia is unclear.We performed a prospective, multicenter, observational study to derive and validate a ratio of serum sFlt-1 to PlGF that would be predictive of the absence or presence of preeclampsia in the short term in women with singleton pregnancies in whom preeclampsia was suspected (24 weeks 0 days to 36 weeks 6 days of gestation). Primary objectives were to assess whether low sFlt-1:PlGF ratios (at or below a derived cutoff) predict the absence of preeclampsia within 1 week after the first visit and whether high ratios (above the cutoff) predict the presence of preeclampsia within 4 weeks.In the development cohort (500 women), we identified an sFlt-1:PlGF ratio cutoff of 38 as having important predictive value. In a subsequent validation study among an additional 550 women, an sFlt-1:PlGF ratio of 38 or lower had a negative predictive value (i.e., no preeclampsia in the subsequent week) of 99.3% (95% confidence interval [CI], 97.9 to 99.9), with 80.0% sensitivity (95% CI, 51.9 to 95.7) and 78.3% specificity (95% CI, 74.6 to 81.7). The positive predictive value of an sFlt-1:PlGF ratio above 38 for a diagnosis of preeclampsia within 4 weeks was 36.7% (95% CI, 28.4 to 45.7), with 66.2% sensitivity (95% CI, 54.0 to 77.0) and 83.1% specificity (95% CI, 79.4 to 86.3).An sFlt-1:PlGF ratio of 38 or lower can be used to predict the short-term absence of preeclampsia in women in whom the syndrome is suspected clinically. (Funded by Roche Diagnostics.).
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spelling oxford-uuid:e7c3887e-56c0-4bb0-abb2-df076c50d41b2022-03-27T10:41:32ZPredictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e7c3887e-56c0-4bb0-abb2-df076c50d41bEnglishSymplectic Elements at Oxford2016Zeisler, HLlurba, EChantraine, FVatish, MStaff, ASennström, MOlovsson, MBrennecke, SStepan, HAllegranza, DDilba, PSchoedl, MHund, MVerlohren, SThe ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in women with suspected preeclampsia is unclear.We performed a prospective, multicenter, observational study to derive and validate a ratio of serum sFlt-1 to PlGF that would be predictive of the absence or presence of preeclampsia in the short term in women with singleton pregnancies in whom preeclampsia was suspected (24 weeks 0 days to 36 weeks 6 days of gestation). Primary objectives were to assess whether low sFlt-1:PlGF ratios (at or below a derived cutoff) predict the absence of preeclampsia within 1 week after the first visit and whether high ratios (above the cutoff) predict the presence of preeclampsia within 4 weeks.In the development cohort (500 women), we identified an sFlt-1:PlGF ratio cutoff of 38 as having important predictive value. In a subsequent validation study among an additional 550 women, an sFlt-1:PlGF ratio of 38 or lower had a negative predictive value (i.e., no preeclampsia in the subsequent week) of 99.3% (95% confidence interval [CI], 97.9 to 99.9), with 80.0% sensitivity (95% CI, 51.9 to 95.7) and 78.3% specificity (95% CI, 74.6 to 81.7). The positive predictive value of an sFlt-1:PlGF ratio above 38 for a diagnosis of preeclampsia within 4 weeks was 36.7% (95% CI, 28.4 to 45.7), with 66.2% sensitivity (95% CI, 54.0 to 77.0) and 83.1% specificity (95% CI, 79.4 to 86.3).An sFlt-1:PlGF ratio of 38 or lower can be used to predict the short-term absence of preeclampsia in women in whom the syndrome is suspected clinically. (Funded by Roche Diagnostics.).
spellingShingle Zeisler, H
Llurba, E
Chantraine, F
Vatish, M
Staff, A
Sennström, M
Olovsson, M
Brennecke, S
Stepan, H
Allegranza, D
Dilba, P
Schoedl, M
Hund, M
Verlohren, S
Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
title Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
title_full Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
title_fullStr Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
title_full_unstemmed Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
title_short Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
title_sort predictive value of the sflt 1 plgf ratio in women with suspected preeclampsia
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