Genomic inflation factors under polygenic inheritance.

Genomic inflation factors under polygenic inheritance.

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Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean test statistic for association calculated from multiple single-nucleotide-polymorphisms across the genome i...

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Main Authors: Yang, J, Weedon, M, Purcell, S, Lettre, G, Estrada, K, Willer, C, Smith, A, Ingelsson, E, O'Connell, JR, Mangino, M, Mägi, R, Madden, P, Heath, A, Nyholt, DR, Martin, N, Montgomery, G, Frayling, T, Hirschhorn, J, McCarthy, M, Goddard, M, Visscher, P
Formato: Journal article
Idioma:English
Publicado: 2011

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