Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast.

Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast.

Nucleotide synthesis is a universal response to DNA damage, but how this response facilitates DNA repair and cell survival is unclear. Here we establish a role for DNA damage-induced nucleotide synthesis in homologous recombination (HR) repair in fission yeast. Using a genetic screen, we found the D...

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Váldodahkkit: Moss, J, Tinline-Purvis, H, Walker, C, Folkes, L, Stratford, MR, Hayles, J, Hoe, K, Kim, D, Park, H, Kearsey, S, Fleck, O, Holmberg, C, Nielsen, O, Humphrey, T
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2010

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