Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by an uncharacterized, arrestin-independent mechanism. Here we use an iterative, discovery-based proteomic approach to show that following opioi...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Schattauer, SS, Land, BB, Reichard, KL, Abraham, AD, Burgeno, LM, Kuhar, JR, Phillips, PEM, Ong, SE, Chavkin, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Nature Publishing Group 2017