Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars
Acetonides are the only protecting groups used in the syntheses of isoDAB from d-ribose and of isoLAB from d-tagatose. isoDAB is a potent and highly specific competitive α-glucosidase inhibitor (for rice α-glucosidase, Ki = 4 μM for isoDAB compared to K i 14 μM for DAB). isoDAB is not an - whereas D...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797101195768102912 |
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| author | Best, D Jenkinson, S Saville, A Alonzi, D Wormald, M Butters, T Norez, C Becq, F Bleriot, Y Adachi, I Kato, A Fleet, G |
| author_facet | Best, D Jenkinson, S Saville, A Alonzi, D Wormald, M Butters, T Norez, C Becq, F Bleriot, Y Adachi, I Kato, A Fleet, G |
| author_sort | Best, D |
| collection | OXFORD |
| description | Acetonides are the only protecting groups used in the syntheses of isoDAB from d-ribose and of isoLAB from d-tagatose. isoDAB is a potent and highly specific competitive α-glucosidase inhibitor (for rice α-glucosidase, Ki = 4 μM for isoDAB compared to K i 14 μM for DAB). isoDAB is not an - whereas DAB is a potent - inhibitor of glycogen phosphorylase. This is the first example of any potent inhibition of glycosidases by a carbon-branched iminosugar pyrrolidine. Although isoLAB shows no inhibition of any glycosidase, preliminary experiments suggest that isoLAB partially rescues the defective F508del-CFTR function and so may have a role in the study of cystic fibrosis. © 2010 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-07T05:48:24Z |
| format | Journal article |
| id | oxford-uuid:e7ff4e99-4eb2-4bbd-bd39-335c5741d3b0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:48:24Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:e7ff4e99-4eb2-4bbd-bd39-335c5741d3b02022-03-27T10:43:22ZCystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugarsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e7ff4e99-4eb2-4bbd-bd39-335c5741d3b0EnglishSymplectic Elements at Oxford2010Best, DJenkinson, SSaville, AAlonzi, DWormald, MButters, TNorez, CBecq, FBleriot, YAdachi, IKato, AFleet, GAcetonides are the only protecting groups used in the syntheses of isoDAB from d-ribose and of isoLAB from d-tagatose. isoDAB is a potent and highly specific competitive α-glucosidase inhibitor (for rice α-glucosidase, Ki = 4 μM for isoDAB compared to K i 14 μM for DAB). isoDAB is not an - whereas DAB is a potent - inhibitor of glycogen phosphorylase. This is the first example of any potent inhibition of glycosidases by a carbon-branched iminosugar pyrrolidine. Although isoLAB shows no inhibition of any glycosidase, preliminary experiments suggest that isoLAB partially rescues the defective F508del-CFTR function and so may have a role in the study of cystic fibrosis. © 2010 Elsevier Ltd. All rights reserved. |
| spellingShingle | Best, D Jenkinson, S Saville, A Alonzi, D Wormald, M Butters, T Norez, C Becq, F Bleriot, Y Adachi, I Kato, A Fleet, G Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars |
| title | Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars |
| title_full | Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars |
| title_fullStr | Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars |
| title_full_unstemmed | Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars |
| title_short | Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars |
| title_sort | cystic fibrosis and diabetes isolab and isodab enantiomeric carbon branched pyrrolidine iminosugars |
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