Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

Acetonides are the only protecting groups used in the syntheses of isoDAB from d-ribose and of isoLAB from d-tagatose. isoDAB is a potent and highly specific competitive α-glucosidase inhibitor (for rice α-glucosidase, Ki = 4 μM for isoDAB compared to K i 14 μM for DAB). isoDAB is not an - whereas D...

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Bibliographic Details
Main Authors:	Best, D, Jenkinson, S, Saville, A, Alonzi, D, Wormald, M, Butters, T, Norez, C, Becq, F, Bleriot, Y, Adachi, I, Kato, A, Fleet, G
Format:	Journal article
Language:	English
Published:	2010

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