Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria.
For the treatment of patients with acute falciparum malaria, the combination of artemisinin as a single dose with a single dose of mefloquine was studied in 4 separate prospective trials, comprising 405 adults and 139 children with uncomplicated falciparum malaria in 2 in-patient and 2 rural out-pat...
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
1994
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| _version_ | 1826302502309462016 |
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| author | Tran, T Arnold, K Nguyen, T Pham, P Nguyen, T Bui, M Le, M Mach, Q Le, H Pham, P |
| author_facet | Tran, T Arnold, K Nguyen, T Pham, P Nguyen, T Bui, M Le, M Mach, Q Le, H Pham, P |
| author_sort | Tran, T |
| collection | OXFORD |
| description | For the treatment of patients with acute falciparum malaria, the combination of artemisinin as a single dose with a single dose of mefloquine was studied in 4 separate prospective trials, comprising 405 adults and 139 children with uncomplicated falciparum malaria in 2 in-patient and 2 rural out-patient studies in Viet Nam. Adults received oral artemisinin and children artemisinin suppositories. Randomized comparative treatment schedules were: artemisinin alone for 5 d, mefloquine-sulfadoxine-pyrimethamine (MSP), or quinine plus sulfadoxine-pyrimethamine (SP). Parasite clearance times (PCT) were rapid for artemisinin treated inpatients (90%: 14.8-20.4 h) but also for patients receiving MSP (PCT 90%: 18.0 h) and quinine (PCT 90%: 22.5 h). The recrudescence rate (RI) during a 28 d follow-up period among the patients given artemisinin plus mefloquine was 15% in the adult in-patients and zero in the adult and children out-patients. RI in the artemisinin 5 d treatment group was 33.3%; among those given artemisinin plus SP it was 47.3% in in-patients and in out-patients 46.1%. In the MSP treated out-patients RI was 1.5% in adults and zero in children. Artemisinin as a single dose (oral in adults and as a suppository in children) in combination with mefloquine was effective in rapidly lowering parasitaemia and in preventing recrudescence in hospital in-patients and in out-patients attending a rural health clinic. MSP alone as a single dose also rapidly reduced parasitaemia (but not as quickly as the artemisinin-mefloquine combination in out-patient children) and prevented recrudescence. |
| first_indexed | 2024-03-07T05:48:31Z |
| format | Journal article |
| id | oxford-uuid:e80844d2-a252-4dc4-9ba6-41c2eac1f45c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:48:31Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:e80844d2-a252-4dc4-9ba6-41c2eac1f45c2022-03-27T10:43:41ZSingle dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e80844d2-a252-4dc4-9ba6-41c2eac1f45cEnglishSymplectic Elements at Oxford1994Tran, TArnold, KNguyen, TPham, PNguyen, TBui, MLe, MMach, QLe, HPham, PFor the treatment of patients with acute falciparum malaria, the combination of artemisinin as a single dose with a single dose of mefloquine was studied in 4 separate prospective trials, comprising 405 adults and 139 children with uncomplicated falciparum malaria in 2 in-patient and 2 rural out-patient studies in Viet Nam. Adults received oral artemisinin and children artemisinin suppositories. Randomized comparative treatment schedules were: artemisinin alone for 5 d, mefloquine-sulfadoxine-pyrimethamine (MSP), or quinine plus sulfadoxine-pyrimethamine (SP). Parasite clearance times (PCT) were rapid for artemisinin treated inpatients (90%: 14.8-20.4 h) but also for patients receiving MSP (PCT 90%: 18.0 h) and quinine (PCT 90%: 22.5 h). The recrudescence rate (RI) during a 28 d follow-up period among the patients given artemisinin plus mefloquine was 15% in the adult in-patients and zero in the adult and children out-patients. RI in the artemisinin 5 d treatment group was 33.3%; among those given artemisinin plus SP it was 47.3% in in-patients and in out-patients 46.1%. In the MSP treated out-patients RI was 1.5% in adults and zero in children. Artemisinin as a single dose (oral in adults and as a suppository in children) in combination with mefloquine was effective in rapidly lowering parasitaemia and in preventing recrudescence in hospital in-patients and in out-patients attending a rural health clinic. MSP alone as a single dose also rapidly reduced parasitaemia (but not as quickly as the artemisinin-mefloquine combination in out-patient children) and prevented recrudescence. |
| spellingShingle | Tran, T Arnold, K Nguyen, T Pham, P Nguyen, T Bui, M Le, M Mach, Q Le, H Pham, P Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. |
| title | Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. |
| title_full | Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. |
| title_fullStr | Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. |
| title_full_unstemmed | Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. |
| title_short | Single dose artemisinin-mefloquine treatment for acute uncomplicated falciparum malaria. |
| title_sort | single dose artemisinin mefloquine treatment for acute uncomplicated falciparum malaria |
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