Time-dependent control of metabolic systems by external effectors.

The expression of elasticity coefficients for time-dependent enzyme inhibition/activation by an external effector was initially derived. Only a limited number of restrictive assumptions were used, for example, the enzyme was considered to obey Michaelis-Menten kinetics and effectors were taken to be...

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Main Authors: Szedlacsek, SE, Aricescu, A, Havsteen, B
Format: Journal article
Language:English
Published: 1996
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author Szedlacsek, SE
Aricescu, A
Havsteen, B
author_facet Szedlacsek, SE
Aricescu, A
Havsteen, B
author_sort Szedlacsek, SE
collection OXFORD
description The expression of elasticity coefficients for time-dependent enzyme inhibition/activation by an external effector was initially derived. Only a limited number of restrictive assumptions were used, for example, the enzyme was considered to obey Michaelis-Menten kinetics and effectors were taken to be competitive. Then, a simple metabolic system under the control of a time-dependent effector (inhibitor or activator) was analysed and the expressions of the control coefficients were obtained. In addition, two numerical examples were used to represent the control coefficients as functions of time and effector concentration. The results indicate that the control coefficients vary in a relatively limited range of values; however, for certain intervals of time and of effector concentration local minima or major modifications of the coefficients may be recorded. The physiological importance of non-steady state analysis of metabolic systems controlled by external effectors was also discussed. It was stressed that the non-steady state treatment may contribute to creating a more realistic image of the metabolic control processes.
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spelling oxford-uuid:e80a2074-5c19-4e36-936c-a4c0d7f5c1892022-03-27T10:43:41ZTime-dependent control of metabolic systems by external effectors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e80a2074-5c19-4e36-936c-a4c0d7f5c189EnglishSymplectic Elements at Oxford1996Szedlacsek, SEAricescu, AHavsteen, BThe expression of elasticity coefficients for time-dependent enzyme inhibition/activation by an external effector was initially derived. Only a limited number of restrictive assumptions were used, for example, the enzyme was considered to obey Michaelis-Menten kinetics and effectors were taken to be competitive. Then, a simple metabolic system under the control of a time-dependent effector (inhibitor or activator) was analysed and the expressions of the control coefficients were obtained. In addition, two numerical examples were used to represent the control coefficients as functions of time and effector concentration. The results indicate that the control coefficients vary in a relatively limited range of values; however, for certain intervals of time and of effector concentration local minima or major modifications of the coefficients may be recorded. The physiological importance of non-steady state analysis of metabolic systems controlled by external effectors was also discussed. It was stressed that the non-steady state treatment may contribute to creating a more realistic image of the metabolic control processes.
spellingShingle Szedlacsek, SE
Aricescu, A
Havsteen, B
Time-dependent control of metabolic systems by external effectors.
title Time-dependent control of metabolic systems by external effectors.
title_full Time-dependent control of metabolic systems by external effectors.
title_fullStr Time-dependent control of metabolic systems by external effectors.
title_full_unstemmed Time-dependent control of metabolic systems by external effectors.
title_short Time-dependent control of metabolic systems by external effectors.
title_sort time dependent control of metabolic systems by external effectors
work_keys_str_mv AT szedlacsekse timedependentcontrolofmetabolicsystemsbyexternaleffectors
AT aricescua timedependentcontrolofmetabolicsystemsbyexternaleffectors
AT havsteenb timedependentcontrolofmetabolicsystemsbyexternaleffectors