Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.
The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malon...
Asıl Yazarlar: | Hamed, R, Henry, L, Gomez-Castellanos, JR, Mecinović, J, Ducho, C, Sorensen, J, Claridge, T, Schofield, C |
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Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
2012
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