Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.

Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.

The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malon...

書誌詳細
主要な著者:	Hamed, R, Henry, L, Gomez-Castellanos, JR, Mecinović, J, Ducho, C, Sorensen, J, Claridge, T, Schofield, C
フォーマット:	Journal article
言語:	English
出版事項:	2012

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