Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.

Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.

The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malon...

书目详细资料
Main Authors:	Hamed, R, Henry, L, Gomez-Castellanos, JR, Mecinović, J, Ducho, C, Sorensen, J, Claridge, T, Schofield, C
格式:	Journal article
语言:	English
出版:	2012

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