Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants.
BACKGROUND: To combat the pandemic of human immunodeficiency virus 1 (HIV-1), a successful vaccine will need to cope with the variability of transmissible viruses. Human hosts infected with HIV-1 potentially harbour many viral variants but very little is known about viruses that are likely to be tra...
| Main Authors: | , , , , , , , , , |
|---|---|
| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
2011
|
| _version_ | 1826302615776919552 |
|---|---|
| author | English, S Katzourakis, A Bonsall, D Flanagan, P Duda, A Fidler, S Weber, J McClure, M Phillips, R Frater, J |
| author_facet | English, S Katzourakis, A Bonsall, D Flanagan, P Duda, A Fidler, S Weber, J McClure, M Phillips, R Frater, J |
| author_sort | English, S |
| collection | OXFORD |
| description | BACKGROUND: To combat the pandemic of human immunodeficiency virus 1 (HIV-1), a successful vaccine will need to cope with the variability of transmissible viruses. Human hosts infected with HIV-1 potentially harbour many viral variants but very little is known about viruses that are likely to be transmitted, or even if there are viral characteristics that predict enhanced transmission in vivo. We show for the first time that genetic divergence consistent with a single transmission event in vivo can represent several years of pre-transmission evolution. RESULTS: We describe a highly unusual case consistent with a single donor transmitting highly related but distinct HIV-1 variants to two individuals on the same evening. We confirm that the clustering of viral genetic sequences, present within each recipient, is consistent with the history of a single donor across the viral env, gag and pol genes by maximum likelihood and bayesian Markov Chain Monte Carlo based phylogenetic analyses. Based on an uncorrelated, lognormal relaxed clock of env gene evolution calibrated with other datasets, the time since the most recent common ancestor is estimated as 2.86 years prior to transmission (95% confidence interval 1.28 to 4.54 years). CONCLUSION: Our results show that an effective design for a preventative vaccine will need to anticipate extensive HIV-1 diversity within an individual donor as well as diversity at the population level. |
| first_indexed | 2024-03-07T05:50:17Z |
| format | Journal article |
| id | oxford-uuid:e8a25092-4a16-4988-88a7-2ca7a813ac6b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:50:17Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:e8a25092-4a16-4988-88a7-2ca7a813ac6b2022-03-27T10:48:15ZPhylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8a25092-4a16-4988-88a7-2ca7a813ac6bEnglishSymplectic Elements at Oxford2011English, SKatzourakis, ABonsall, DFlanagan, PDuda, AFidler, SWeber, JMcClure, MPhillips, RFrater, JBACKGROUND: To combat the pandemic of human immunodeficiency virus 1 (HIV-1), a successful vaccine will need to cope with the variability of transmissible viruses. Human hosts infected with HIV-1 potentially harbour many viral variants but very little is known about viruses that are likely to be transmitted, or even if there are viral characteristics that predict enhanced transmission in vivo. We show for the first time that genetic divergence consistent with a single transmission event in vivo can represent several years of pre-transmission evolution. RESULTS: We describe a highly unusual case consistent with a single donor transmitting highly related but distinct HIV-1 variants to two individuals on the same evening. We confirm that the clustering of viral genetic sequences, present within each recipient, is consistent with the history of a single donor across the viral env, gag and pol genes by maximum likelihood and bayesian Markov Chain Monte Carlo based phylogenetic analyses. Based on an uncorrelated, lognormal relaxed clock of env gene evolution calibrated with other datasets, the time since the most recent common ancestor is estimated as 2.86 years prior to transmission (95% confidence interval 1.28 to 4.54 years). CONCLUSION: Our results show that an effective design for a preventative vaccine will need to anticipate extensive HIV-1 diversity within an individual donor as well as diversity at the population level. |
| spellingShingle | English, S Katzourakis, A Bonsall, D Flanagan, P Duda, A Fidler, S Weber, J McClure, M Phillips, R Frater, J Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. |
| title | Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. |
| title_full | Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. |
| title_fullStr | Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. |
| title_full_unstemmed | Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. |
| title_short | Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. |
| title_sort | phylogenetic analysis consistent with a clinical history of sexual transmission of hiv 1 from a single donor reveals transmission of highly distinct variants |
| work_keys_str_mv | AT englishs phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT katzourakisa phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT bonsalld phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT flanaganp phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT dudaa phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT fidlers phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT weberj phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT mcclurem phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT phillipsr phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants AT fraterj phylogeneticanalysisconsistentwithaclinicalhistoryofsexualtransmissionofhiv1fromasingledonorrevealstransmissionofhighlydistinctvariants |