Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis
Activating mutations in NRAS account for 20%–30% of melanoma, but despite decades of research and in contrast to BRAF, no effective anti-NRAS therapies have been forthcoming. Here, we identify a previously uncharacterized serine/threonine kinase STK19 as a novel NRAS activator. STK19 phosphorylates...
| Автори: | , , , |
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| Формат: | Journal article |
| Опубліковано: |
Cell Press
2019
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