Mixed-haplotype MHC class II molecules select functional CD4+ T cells.
MHC class II molecules are formed from polymorphic alpha and beta chains. While pairing of chains is most efficient within class II isotypes and haplotypes, limited pairing and surface expression of mixed-haplotype and -isotype class II molecules is common. The function of such molecules in antigen...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797101335369220096 |
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| author | Silk, J Schoendorf, D Bartok, I Chai, J Gray, D Simpson, E Dyson, J |
| author_facet | Silk, J Schoendorf, D Bartok, I Chai, J Gray, D Simpson, E Dyson, J |
| author_sort | Silk, J |
| collection | OXFORD |
| description | MHC class II molecules are formed from polymorphic alpha and beta chains. While pairing of chains is most efficient within class II isotypes and haplotypes, limited pairing and surface expression of mixed-haplotype and -isotype class II molecules is common. The function of such molecules in antigen presentation has been established by the unique restriction of responses in F1 mice. However, it has not been established whether mixed class II molecules are able to mediate selection of functional T cells and how the reduced avidity of the TCR/MHC interaction influences the repertoire. In this report we have addressed these issues through the production of mice expressing solely mixed-haplotype class II molecules. The mixed class II molecules promote selection of a small CD4+ T cell repertoire with modified TCR use. The selected CD4+ T cells are functional in vivo and in vitro. |
| first_indexed | 2024-03-07T05:50:24Z |
| format | Journal article |
| id | oxford-uuid:e8ab02b0-5b73-4c68-b738-3536ad6763c0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:50:24Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:e8ab02b0-5b73-4c68-b738-3536ad6763c02022-03-27T10:48:36ZMixed-haplotype MHC class II molecules select functional CD4+ T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8ab02b0-5b73-4c68-b738-3536ad6763c0EnglishSymplectic Elements at Oxford2005Silk, JSchoendorf, DBartok, IChai, JGray, DSimpson, EDyson, JMHC class II molecules are formed from polymorphic alpha and beta chains. While pairing of chains is most efficient within class II isotypes and haplotypes, limited pairing and surface expression of mixed-haplotype and -isotype class II molecules is common. The function of such molecules in antigen presentation has been established by the unique restriction of responses in F1 mice. However, it has not been established whether mixed class II molecules are able to mediate selection of functional T cells and how the reduced avidity of the TCR/MHC interaction influences the repertoire. In this report we have addressed these issues through the production of mice expressing solely mixed-haplotype class II molecules. The mixed class II molecules promote selection of a small CD4+ T cell repertoire with modified TCR use. The selected CD4+ T cells are functional in vivo and in vitro. |
| spellingShingle | Silk, J Schoendorf, D Bartok, I Chai, J Gray, D Simpson, E Dyson, J Mixed-haplotype MHC class II molecules select functional CD4+ T cells. |
| title | Mixed-haplotype MHC class II molecules select functional CD4+ T cells. |
| title_full | Mixed-haplotype MHC class II molecules select functional CD4+ T cells. |
| title_fullStr | Mixed-haplotype MHC class II molecules select functional CD4+ T cells. |
| title_full_unstemmed | Mixed-haplotype MHC class II molecules select functional CD4+ T cells. |
| title_short | Mixed-haplotype MHC class II molecules select functional CD4+ T cells. |
| title_sort | mixed haplotype mhc class ii molecules select functional cd4 t cells |
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