Membranes as messengers in T cell adhesion signaling.
Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling...
| Principais autores: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2004
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| _version_ | 1826302637544308736 |
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| author | Dustin, M Bivona, T Philips, MR |
| author_facet | Dustin, M Bivona, T Philips, MR |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery of signals may be crucial, and membrane trafficking from endosomes and the Golgi apparatus seem to be essential in delivering the messages from spatially segregated surface receptors. |
| first_indexed | 2024-03-07T05:50:37Z |
| format | Journal article |
| id | oxford-uuid:e8bf606f-99c8-4fba-b51e-adde4fafd64a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:50:37Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:e8bf606f-99c8-4fba-b51e-adde4fafd64a2022-03-27T10:49:05ZMembranes as messengers in T cell adhesion signaling.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8bf606f-99c8-4fba-b51e-adde4fafd64aEnglishSymplectic Elements at Oxford2004Dustin, MBivona, TPhilips, MRTalin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery of signals may be crucial, and membrane trafficking from endosomes and the Golgi apparatus seem to be essential in delivering the messages from spatially segregated surface receptors. |
| spellingShingle | Dustin, M Bivona, T Philips, MR Membranes as messengers in T cell adhesion signaling. |
| title | Membranes as messengers in T cell adhesion signaling. |
| title_full | Membranes as messengers in T cell adhesion signaling. |
| title_fullStr | Membranes as messengers in T cell adhesion signaling. |
| title_full_unstemmed | Membranes as messengers in T cell adhesion signaling. |
| title_short | Membranes as messengers in T cell adhesion signaling. |
| title_sort | membranes as messengers in t cell adhesion signaling |
| work_keys_str_mv | AT dustinm membranesasmessengersintcelladhesionsignaling AT bivonat membranesasmessengersintcelladhesionsignaling AT philipsmr membranesasmessengersintcelladhesionsignaling |