A review of the human Sigma-1 Receptor structure
The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in l...
| Main Authors: | , , |
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| Format: | Book section |
| Language: | English |
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Springer Verlag
2017
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| _version_ | 1797101356041895936 |
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| author | Ossa, F Schnell, J Ortega-Roldan, J |
| author_facet | Ossa, F Schnell, J Ortega-Roldan, J |
| author_sort | Ossa, F |
| collection | OXFORD |
| description | The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an excellent starting point for understanding the molecular tricks employed by this small membrane receptor to modulate a large number of signaling events. Here, we review insights from the structures of ligand-bound S1R in the context of previous biochemical studies and propose, from a structural viewpoint, a set of important future directions. |
| first_indexed | 2024-03-07T05:50:43Z |
| format | Book section |
| id | oxford-uuid:e8c97507-8d82-4e5d-b80a-5476f2ea6a38 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:50:43Z |
| publishDate | 2017 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | oxford-uuid:e8c97507-8d82-4e5d-b80a-5476f2ea6a382022-03-27T10:49:19ZA review of the human Sigma-1 Receptor structureBook sectionhttp://purl.org/coar/resource_type/c_3248uuid:e8c97507-8d82-4e5d-b80a-5476f2ea6a38EnglishSymplectic Elements at OxfordSpringer Verlag2017Ossa, FSchnell, JOrtega-Roldan, JThe Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an excellent starting point for understanding the molecular tricks employed by this small membrane receptor to modulate a large number of signaling events. Here, we review insights from the structures of ligand-bound S1R in the context of previous biochemical studies and propose, from a structural viewpoint, a set of important future directions. |
| spellingShingle | Ossa, F Schnell, J Ortega-Roldan, J A review of the human Sigma-1 Receptor structure |
| title | A review of the human Sigma-1 Receptor structure |
| title_full | A review of the human Sigma-1 Receptor structure |
| title_fullStr | A review of the human Sigma-1 Receptor structure |
| title_full_unstemmed | A review of the human Sigma-1 Receptor structure |
| title_short | A review of the human Sigma-1 Receptor structure |
| title_sort | review of the human sigma 1 receptor structure |
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