Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these responses are largely elusive. Here we show that...

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Bibliografische gegevens
Hoofdauteurs: Mooser, C, Symeonidou, I, Leimbacher, P, Ribeiro, A, Shorrocks, A, Jungmichel, S, Larsen, S, Knechtle, K, Jasrotia, A, Zurbriggen, D, Jeanrenaud, A, Leikauf, C, Fink, D, Nielsen, M, Blackford, A, Stucki, M
Formaat: Journal article
Taal:English
Gepubliceerd in: Nature Research 2020

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