Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these responses are largely elusive. Here we show that...

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Detalles Bibliográficos
Main Authors: Mooser, C, Symeonidou, I, Leimbacher, P, Ribeiro, A, Shorrocks, A, Jungmichel, S, Larsen, S, Knechtle, K, Jasrotia, A, Zurbriggen, D, Jeanrenaud, A, Leikauf, C, Fink, D, Nielsen, M, Blackford, A, Stucki, M
Formato: Journal article
Idioma:English
Publicado: Nature Research 2020

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